Muscle-Specific Overexpression of PGC-1α Does Not Augment Metabolic Improvements in Response to Exercise and Caloric Restriction

This study used mice with muscle-specific overexpression of PGC-1α, a transcriptional coactivator that promotes mitochondrial biogenesis, to determine whether increased oxidative potential facilitates metabolic improvements in response to lifestyle modification. MCK-PGC1α mice and nontransgenic (NT)...

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Detalles Bibliográficos
Autores principales: Wong, Kari E., Mikus, Catherine R., Slentz, Dorothy H., Seiler, Sarah E., DeBalsi, Karen L., Ilkayeva, Olga R., Crain, Karen I., Kinter, Michael T., Kien, C. Lawrence, Stevens, Robert D., Muoio, Deborah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407850/
https://www.ncbi.nlm.nih.gov/pubmed/25422105
http://dx.doi.org/10.2337/db14-0827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407850/
https://www.ncbi.nlm.nih.gov/pubmed/25422105
http://dx.doi.org/10.2337/db14-0827

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