Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes

Diabetes impedes vascular repair and causes vasoregression in the brain after stroke, but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion (I/R) injury inactivates the p85 subunit of phosphoinositide 3-kinase...

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Detalles Bibliográficos
Autores principales: Abdelsaid, Mohammed, Prakash, Roshini, Li, Weiguo, Coucha, Maha, Hafez, Sherif, Johnson, Maribeth H., Fagan, Susan C., Ergul, Adviye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407857/
https://www.ncbi.nlm.nih.gov/pubmed/25524911
http://dx.doi.org/10.2337/db14-1423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407857/
https://www.ncbi.nlm.nih.gov/pubmed/25524911
http://dx.doi.org/10.2337/db14-1423

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