Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

Circulating transthyretin (TTR) is a critical determinant of plasma retinol-binding protein 4 (RBP4) levels. Elevated RBP4 levels cause insulin resistance, and the lowering of RBP4 levels improves glucose homeostasis. Since lowering TTR levels increases renal clearance of RBP4, we determined whether...

Descripción completa

Detalles Bibliográficos
Autores principales: Zemany, Laura, Bhanot, Sanjay, Peroni, Odile D., Murray, Susan F., Moraes-Vieira, Pedro M., Castoldi, Angela, Manchem, Prasad, Guo, Shuling, Monia, Brett P., Kahn, Barbara B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407860/
https://www.ncbi.nlm.nih.gov/pubmed/25524914
http://dx.doi.org/10.2337/db14-0970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407860/
https://www.ncbi.nlm.nih.gov/pubmed/25524914
http://dx.doi.org/10.2337/db14-0970

Ejemplares similares