Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes

The inactive full-length form of GLP-1(1-37) stimulates conversion of both rat and human intestinal epithelial cells into insulin-secreting cells. We investigated whether oral administration of human commensal bacteria engineered to secrete GLP-1(1-37) could ameliorate hyperglycemia in a rat model o...

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Detalles Bibliográficos
Autores principales: Duan, Franklin F., Liu, Joy H., March, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407861/
https://www.ncbi.nlm.nih.gov/pubmed/25626737
http://dx.doi.org/10.2337/db14-0635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407861/
https://www.ncbi.nlm.nih.gov/pubmed/25626737
http://dx.doi.org/10.2337/db14-0635

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