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Oxidative stress conditions increase the frequency of de novo formation of the yeast [PSI (+)] prion

Prions are self‐perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals and heritable traits in yeast. The molecular basis of how yeast and mammalian prions form spontaneously into infectious amyloid‐like structures is poorly understood. We have explored...

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Detalles Bibliográficos
Autores principales: Doronina, Victoria A., Staniforth, Gemma L., Speldewinde, Shaun H., Tuite, Mick F., Grant, Chris M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407919/
https://www.ncbi.nlm.nih.gov/pubmed/25601439
http://dx.doi.org/10.1111/mmi.12930