Pharmacokinetics of Dolutegravir When Administered With Mineral Supplements in Healthy Adult Subjects

All commercially available integrase inhibitors are 2-metal binders and may be affected by co-administration with metal cations. The purpose of this study was to evaluate the effect of calcium and iron supplements on dolutegravir pharmacokinetics and strategies (dose separation and food) to attenuat...

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Detalles Bibliográficos
Autores principales: Song, Ivy, Borland, Julie, Arya, Niki, Wynne, Brian, Piscitelli, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Drug Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407950/
https://www.ncbi.nlm.nih.gov/pubmed/25449994
http://dx.doi.org/10.1002/jcph.439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407950/
https://www.ncbi.nlm.nih.gov/pubmed/25449994
http://dx.doi.org/10.1002/jcph.439

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