The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease

Genome and exome sequencing in large cohorts enables characterization of the role of rare variation in complex diseases. Success in this endeavor, however, requires investigators to test a diverse array of genetic hypotheses which differ in the number, frequency and effect sizes of underlying causal...

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Detalles Bibliográficos
Autores principales: Moutsianas, Loukas, Agarwala, Vineeta, Fuchsberger, Christian, Flannick, Jason, Rivas, Manuel A., Gaulton, Kyle J., Albers, Patrick K., McVean, Gil, Boehnke, Michael, Altshuler, David, McCarthy, Mark I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407972/
https://www.ncbi.nlm.nih.gov/pubmed/25906071
http://dx.doi.org/10.1371/journal.pgen.1005165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407972/
https://www.ncbi.nlm.nih.gov/pubmed/25906071
http://dx.doi.org/10.1371/journal.pgen.1005165

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