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KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair
Homologous recombination and non-homologous end joining are two major DNA double-strand-break repair pathways. While HR-mediated repair requires a homologous sequence as the guiding template to restore the damage site precisely, NHEJ-mediated repair ligates the DNA lesion directly and increases the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408008/ https://www.ncbi.nlm.nih.gov/pubmed/25905708 http://dx.doi.org/10.1371/journal.pone.0123935 |