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Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo
The level of drebrin, an evolutionarily conserved f-actin-binding protein that regulates synaptic structure and function, is reduced in the brains of patients with chronic neurodegenerative diseases such as Alzheimer’s disease (AD) and Down’s syndrome (DS). It was suggested that excitotoxic neuronal...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408054/ https://www.ncbi.nlm.nih.gov/pubmed/25905636 http://dx.doi.org/10.1371/journal.pone.0125119 |