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A second essential function of the Est1-binding arm of yeast telomerase RNA

The enzymatic ribonucleoprotein telomerase maintains telomeres in many eukaryotes, including humans, and plays a central role in aging and cancer. Saccharomyces cerevisiae telomerase RNA, TLC1, is a flexible scaffold that tethers telomerase holoenzyme protein subunits to the complex. Here we test th...

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Detalles Bibliográficos
Autores principales: Lebo, Kevin J., Niederer, Rachel O., Zappulla, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408794/
https://www.ncbi.nlm.nih.gov/pubmed/25737580
http://dx.doi.org/10.1261/rna.049379.114