The methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons

Mutations in the human X-linked gene MECP2 are responsible for most Rett syndrome (RTT) cases, predominantly within its methyl-CpG-binding domain (MBD). To examine the role of MBD in the pathogenesis of RTT, we generated two MeCP2 mutant constructs, one with a deletion of MBD (MeCP2-ΔMBD), another m...

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Detalles Bibliográficos
Autores principales: Zhao, Na, Ma, Dongliang, Leong, Wan Ying, Han, Ju, VanDongen, Antonius, Chen, Teng, Goh, Eyleen L. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408855/
https://www.ncbi.nlm.nih.gov/pubmed/25964742
http://dx.doi.org/10.3389/fncel.2015.00158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408855/
https://www.ncbi.nlm.nih.gov/pubmed/25964742
http://dx.doi.org/10.3389/fncel.2015.00158

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