BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

Homologous recombination plays a key role in the repair of double-strand breaks (DSBs), and thereby significantly contributes to cellular tolerance to radiotherapy and some chemotherapy. DSB repair by homologous recombination is initiated by 5’ to 3’ strand resection (DSB resection), with nucleases...

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Detalles Bibliográficos
Autores principales: Hoa, Nguyen Ngoc, Kobayashi, Junya, Omura, Masato, Hirakawa, Mayumi, Yang, Soo-Hyun, Komatsu, Kenshi, Paull, Tanya T., Takeda, Shunichi, Sasanuma, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409214/
https://www.ncbi.nlm.nih.gov/pubmed/25909997
http://dx.doi.org/10.1371/journal.pone.0124495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409214/
https://www.ncbi.nlm.nih.gov/pubmed/25909997
http://dx.doi.org/10.1371/journal.pone.0124495

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