Using Visualized Matrix Effects to Develop and Improve LC-MS/MS Bioanalytical Methods, Taking TRAM-34 as an Example

Matrix effects (MEs) continue to be an obstacle in the development of the LC-MS/MS method, with phospholipids being the major cause of MEs. Changing the mobile phase has been a common strategy to reduce MEs; however, the underlying mechanism is unclear. "In-source multiple-reaction monitoring&q...

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Detalles Bibliográficos
Autores principales: Ye, Jia-Hung, Pao, Li-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409340/
https://www.ncbi.nlm.nih.gov/pubmed/25909956
http://dx.doi.org/10.1371/journal.pone.0118818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409340/
https://www.ncbi.nlm.nih.gov/pubmed/25909956
http://dx.doi.org/10.1371/journal.pone.0118818

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