DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism for maintaining cellular memory during self-renewal. Although DNA methyltransferases (DNMTs) are dispensable for embryonic ste...

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Detalles Bibliográficos
Autores principales: Pathania, Rajneesh, Ramachandran, Sabarish, Elangovan, Selvakumar, Padia, Ravi, Yang, Pengyi, Cinghu, Senthilkumar, Veeranan-Karmegam, Rajalakshmi, Arjunan, Pachiappan, Gnana-Prakasam, Jaya P., Fulzele, Sadanand, Pei, Lirong, Chang, Chang-Sheng, Choi, Hyeon, Shi, Huidong, Manicassamy, Santhakumar, Prasad, Puttur D., Sharma, Suash, Ganapathy, Vadivel, Jothi, Raja, Thangaraju, Muthusamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410389/
https://www.ncbi.nlm.nih.gov/pubmed/25908435
http://dx.doi.org/10.1038/ncomms7910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410389/
https://www.ncbi.nlm.nih.gov/pubmed/25908435
http://dx.doi.org/10.1038/ncomms7910

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