VarSim: a high-fidelity simulation and validation framework for high-throughput genome sequencing with cancer applications

Summary: VarSim is a framework for assessing alignment and variant calling accuracy in high-throughput genome sequencing through simulation or real data. In contrast to simulating a random mutation spectrum, it synthesizes diploid genomes with germline and somatic mutations based on a realistic mode...

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Detalles Bibliográficos
Autores principales: Mu, John C., Mohiyuddin, Marghoob, Li, Jian, Bani Asadi, Narges, Gerstein, Mark B., Abyzov, Alexej, Wong, Wing H., Lam, Hugo Y.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410653/
https://www.ncbi.nlm.nih.gov/pubmed/25524895
http://dx.doi.org/10.1093/bioinformatics/btu828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410653/
https://www.ncbi.nlm.nih.gov/pubmed/25524895
http://dx.doi.org/10.1093/bioinformatics/btu828

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