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VarSim: a high-fidelity simulation and validation framework for high-throughput genome sequencing with cancer applications

Summary: VarSim is a framework for assessing alignment and variant calling accuracy in high-throughput genome sequencing through simulation or real data. In contrast to simulating a random mutation spectrum, it synthesizes diploid genomes with germline and somatic mutations based on a realistic mode...

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Detalles Bibliográficos
Autores principales:	Mu, John C., Mohiyuddin, Marghoob, Li, Jian, Bani Asadi, Narges, Gerstein, Mark B., Abyzov, Alexej, Wong, Wing H., Lam, Hugo Y.K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Applications Notes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410653/ https://www.ncbi.nlm.nih.gov/pubmed/25524895 http://dx.doi.org/10.1093/bioinformatics/btu828

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