Eltrombopag Modulates Reactive Oxygen Species and Decreases Acute Myeloid Leukemia Cell Survival

Previous studies have demonstrated that the small molecule thrombopoietin (TPO) mimetic, eltrombopag (E), induces apoptosis in acute myeloid leukemia (AML) cells. Here, we sought to define the mechanism of the anti-leukemic effect of eltrombopag. Our studies demonstrate that, at a concentration of 5...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalota, Anna, Selak, Mary A., Garcia-Cid, Laura A., Carroll, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411049/
https://www.ncbi.nlm.nih.gov/pubmed/25915523
http://dx.doi.org/10.1371/journal.pone.0126691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411049/
https://www.ncbi.nlm.nih.gov/pubmed/25915523
http://dx.doi.org/10.1371/journal.pone.0126691

Ejemplares similares