Genetic Polymorphisms of Dihydropyrimidinase in a Japanese Patient with Capecitabine-Induced Toxicity

Dihydropyrimidinase (DHP) is the second enzyme in the catabolic pathway of uracil, thymine, and chemotherapeutic fluoropyrimidine agents such as 5-fluorouracil (5-FU). Thus, DHP deficiency might be associated with 5-FU toxicity during fluoropyrimidine chemotherapy. We performed genetic analyses of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hiratsuka, Masahiro, Yamashita, Hiroshi, Akai, Fumika, Hosono, Hiroki, Hishinuma, Eiji, Hirasawa, Noriyasu, Mori, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411063/
https://www.ncbi.nlm.nih.gov/pubmed/25915935
http://dx.doi.org/10.1371/journal.pone.0124818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411063/
https://www.ncbi.nlm.nih.gov/pubmed/25915935
http://dx.doi.org/10.1371/journal.pone.0124818

Ejemplares similares