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Genetic Polymorphisms of Dihydropyrimidinase in a Japanese Patient with Capecitabine-Induced Toxicity

Dihydropyrimidinase (DHP) is the second enzyme in the catabolic pathway of uracil, thymine, and chemotherapeutic fluoropyrimidine agents such as 5-fluorouracil (5-FU). Thus, DHP deficiency might be associated with 5-FU toxicity during fluoropyrimidine chemotherapy. We performed genetic analyses of t...

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Detalles Bibliográficos
Autores principales:	Hiratsuka, Masahiro, Yamashita, Hiroshi, Akai, Fumika, Hosono, Hiroki, Hishinuma, Eiji, Hirasawa, Noriyasu, Mori, Takahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411063/ https://www.ncbi.nlm.nih.gov/pubmed/25915935 http://dx.doi.org/10.1371/journal.pone.0124818

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