Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis

Multiple sclerosis (MS) is characterized by inflammatory demyelination and deposition of fibrinogen in the central nervous system (CNS). Elevated levels of a critical inhibitor of the mammalian fibrinolitic system, plasminogen activator inhibitor 1 (PAI-1) have been demonstrated in human and animal...

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Detalles Bibliográficos
Autores principales: Pelisch, Nicolas, Dan, Takashi, Ichimura, Atsuhiko, Sekiguchi, Hiroki, Vaughan, Douglas E., van Ypersele de Strihou, Charles, Miyata, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411110/
https://www.ncbi.nlm.nih.gov/pubmed/25915660
http://dx.doi.org/10.1371/journal.pone.0124510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411110/
https://www.ncbi.nlm.nih.gov/pubmed/25915660
http://dx.doi.org/10.1371/journal.pone.0124510

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