Hsp70 in cancer: back to the future

Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell sign...

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Detalles Bibliográficos
Autores principales: Sherman, Michael Y., Gabai, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411196/
https://www.ncbi.nlm.nih.gov/pubmed/25347739
http://dx.doi.org/10.1038/onc.2014.349
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author Sherman, Michael Y.
Gabai, Vladimir L.
author_facet Sherman, Michael Y.
Gabai, Vladimir L.
author_sort Sherman, Michael Y.
collection PubMed
description Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell signaling. A major factor that directs Hsp70 signaling activity appears to be the co-chaperone Bag3. Here, we review these recent breakthroughs, and how these discoveries drive drug development efforts.
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spelling pubmed-44111962016-02-06 Hsp70 in cancer: back to the future Sherman, Michael Y. Gabai, Vladimir L. Oncogene Article Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell signaling. A major factor that directs Hsp70 signaling activity appears to be the co-chaperone Bag3. Here, we review these recent breakthroughs, and how these discoveries drive drug development efforts. 2014-10-27 2015-08-06 /pmc/articles/PMC4411196/ /pubmed/25347739 http://dx.doi.org/10.1038/onc.2014.349 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Sherman, Michael Y.
Gabai, Vladimir L.
Hsp70 in cancer: back to the future
title Hsp70 in cancer: back to the future
title_full Hsp70 in cancer: back to the future
title_fullStr Hsp70 in cancer: back to the future
title_full_unstemmed Hsp70 in cancer: back to the future
title_short Hsp70 in cancer: back to the future
title_sort hsp70 in cancer: back to the future
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411196/
https://www.ncbi.nlm.nih.gov/pubmed/25347739
http://dx.doi.org/10.1038/onc.2014.349
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