Targeting the late component of the cardiac L-type Ca(2+) current to suppress early afterdepolarizations

Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature extrasystoles, triggering focal and reentrant arrhythmias. Because the L-type Ca(2+) current (I(Ca,L)) plays a key role in both AP prolongation...

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Detalles Bibliográficos
Autores principales: Madhvani, Roshni V., Angelini, Marina, Xie, Yuanfang, Pantazis, Antonios, Suriany, Silvie, Borgstrom, Nils P., Garfinkel, Alan, Qu, Zhilin, Weiss, James N., Olcese, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411259/
https://www.ncbi.nlm.nih.gov/pubmed/25918358
http://dx.doi.org/10.1085/jgp.201411288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411259/
https://www.ncbi.nlm.nih.gov/pubmed/25918358
http://dx.doi.org/10.1085/jgp.201411288

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