Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell killing

Although studies suggest that perturbing mitotic progression leads to DNA damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. We show that BuGZ and Bub3, which are two mitotic regulators localized in the...

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Detalles Bibliográficos
Autores principales: Wan, Yihan, Zheng, Xiaobin, Chen, Haiyang, Guo, Yuxuan, Jiang, Hao, He, Xiaonan, Zhu, Xueliang, Zheng, Yixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411280/
https://www.ncbi.nlm.nih.gov/pubmed/25918225
http://dx.doi.org/10.1083/jcb.201409073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411280/
https://www.ncbi.nlm.nih.gov/pubmed/25918225
http://dx.doi.org/10.1083/jcb.201409073

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