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Too packed to change: side-chain packing and site-specific substitution rates in protein evolution

In protein evolution, due to functional and biophysical constraints, the rates of amino acid substitution differ from site to site. Among the best predictors of site-specific rates are solvent accessibility and packing density. The packing density measure that best correlates with rates is the weigh...

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Detalles Bibliográficos
Autores principales: Marcos, María Laura, Echave, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411540/
https://www.ncbi.nlm.nih.gov/pubmed/25922797
http://dx.doi.org/10.7717/peerj.911