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Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats
BACKGROUND: Mefloquine can cross the blood–brain barrier and block the gap junction intercellular communication in the brain. Enhanced electrical coupling mediated by gap junctions is an underlying mechanism involved in the generation and maintenance of seizures. For this reason, the aim of this stu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411716/ https://www.ncbi.nlm.nih.gov/pubmed/25886955 http://dx.doi.org/10.1186/s12868-015-0145-7 |