Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas

BACKGROUND: Rb1 is the most frequently mutated gene in the pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high E2F levels following pRB loss also induce apoptosis-promoting genes as a safeguard mechanism to suppress emer...

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Detalles Bibliográficos
Autores principales: Xie, Chencheng, Lu, Huarui, Nomura, Alice, Hanse, Eric Allan, Forster, Colleen Lynn, Parker, Josh Berken, Linden, Michael Andrew, Karasch, Chris, Hallstrom, Timothy Curtis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411757/
https://www.ncbi.nlm.nih.gov/pubmed/25907958
http://dx.doi.org/10.1186/s12943-015-0360-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411757/
https://www.ncbi.nlm.nih.gov/pubmed/25907958
http://dx.doi.org/10.1186/s12943-015-0360-y

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