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Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas
BACKGROUND: Rb1 is the most frequently mutated gene in the pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high E2F levels following pRB loss also induce apoptosis-promoting genes as a safeguard mechanism to suppress emer...
Autores principales: | Xie, Chencheng, Lu, Huarui, Nomura, Alice, Hanse, Eric Allan, Forster, Colleen Lynn, Parker, Josh Berken, Linden, Michael Andrew, Karasch, Chris, Hallstrom, Timothy Curtis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411757/ https://www.ncbi.nlm.nih.gov/pubmed/25907958 http://dx.doi.org/10.1186/s12943-015-0360-y |
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