Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

BACKGROUND: Multiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells, leading to neuroinflammation, demyelination...

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Detalles Bibliográficos
Autores principales: Mandler, Markus, Valera, Elvira, Rockenstein, Edward, Mante, Michael, Weninger, Harald, Patrick, Christina, Adame, Anthony, Schmidhuber, Sabine, Santic, Radmila, Schneeberger, Achim, Schmidt, Walter, Mattner, Frank, Masliah, Eliezer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411775/
https://www.ncbi.nlm.nih.gov/pubmed/25886309
http://dx.doi.org/10.1186/s13024-015-0008-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411775/
https://www.ncbi.nlm.nih.gov/pubmed/25886309
http://dx.doi.org/10.1186/s13024-015-0008-9

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