Cargando…

Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features

BACKGROUND: Breast cancer is a complex heterogeneous disease and is one of the leading causes of death among women. In addressing the need for treatments of this life-threatening illness, we studied 3,4-dihydropyrimidin-2(1H)-one (or thione) derivatives (DHPMs), a class of inhibitor molecules of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guido, Bruna C, Ramos, Luciana M, Nolasco, Diego O, Nobrega, Catharine C, Andrade, Bárbara YG, Pic-Taylor, Aline, Neto, Brenno AD, Corrêa, José R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411898/ https://www.ncbi.nlm.nih.gov/pubmed/25885813 http://dx.doi.org/10.1186/s12885-015-1274-1

Ejemplares similares

Non‐canonical functions of the mitotic kinesin Eg5
por: Liu, Min, et al.
Publicado: (2018)

Kinesin-14 HSET may not oppose kinesin-5 Eg5 activity in RPE-1 cells
por: Carlier-Grynkorn, Frederique, et al.
Publicado: (2022)

Kinesin molecular motor Eg5 functions during polypeptide synthesis
por: Bartoli, Kristen M., et al.
Publicado: (2011)

Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5
por: Exertier, Prisca, et al.
Publicado: (2013)

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles
por: Miyamoto, David T., et al.
Publicado: (2004)

Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment
por: Marconi, Guya Diletta, et al.
Publicado: (2019)

Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
por: She, Zhen-Yu, et al.
Publicado: (2020)

Kinesin-5 Eg5 is essential for spindle assembly, chromosome stability and organogenesis in development
por: Yu, Wen-Xin, et al.
Publicado: (2022)

Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule
por: Guo, Wenhan, et al.
Publicado: (2022)

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5
por: Kapoor, Tarun M., et al.
Publicado: (2000)

Lamin B Counteracts the Kinesin Eg5 to Restrain Spindle Pole Separation during Spindle Assembly
por: Goodman, Benjamin, et al.
Publicado: (2010)

Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness
por: Wissing, Michel D., et al.
Publicado: (2014)

Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface
por: Wakana, Yuichi, et al.
Publicado: (2013)

The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle
por: Mountain, Vicki, et al.
Publicado: (1999)

Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors
por: Yokoyama, Hideshi, et al.
Publicado: (2018)

Ammonium Trifluoroacetate-Mediated Synthesis of 3,4-dihydropyrimidin-2(1H)-ones
por: Raju, Chandran, et al.
Publicado: (2011)

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions
por: Sánchez-Sancho, Francisco, et al.
Publicado: (2022)

Computational fragment-based drug design to explore the hydrophobic subpocket of the mitotic kinesin Eg5 allosteric binding site
por: Oguievetskaia, Ksenia, et al.
Publicado: (2010)

Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model
por: Ricci, Alessia, et al.
Publicado: (2022)

Antimicrobial evaluation of some novel derivatives of 3,4-dihydropyrimidine-2(1H)-one
por: Jalali, M., et al.
Publicado: (2012)

3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking
por: Luo, Xingyan, et al.
Publicado: (2012)

Kinesin Eg5 Selective Inhibition by Newly Synthesized Molecules as an Alternative Approach to Counteract Breast Cancer Progression: An In Vitro Study
por: Ricci, Alessia, et al.
Publicado: (2022)

Integrated Machine Learning and Chemoinformatics-Based Screening of Mycotic Compounds against Kinesin Spindle ProteinEg5 for Lung Cancer Therapy
por: Maiti, Priyanka, et al.
Publicado: (2022)

Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation
por: Vukušić, Kruno, et al.
Publicado: (2021)

Synthesis of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones via sequential Biginelli and Passerini reactions
por: Boukis, Andreas C, et al.
Publicado: (2017)

2,6-Diamino-4-oxo-3,4-dihydropyrimidin-1-ium chloride dihydrate
por: Suleiman Gwaram, Nura, et al.
Publicado: (2010)

The kinesin Eg5 inhibitor K858 exerts antiproliferative and proapoptotic effects and attenuates the invasive potential of head and neck squamous carcinoma cells
por: Nicolai, Alice, et al.
Publicado: (2022)

Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity
por: Milano, G, et al.
Publicado: (1999)

Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe
por: de With, M., et al.
Publicado: (2023)

Dihydropyrimidine Dehydrogenase Deficiency: To Screen or Not to Screen?
por: Vogel, Wendy H., et al.
Publicado: (2020)

EGS4 shower display system, EGS4PICT(2), windows version
por: Hirayama, H, et al.
Publicado: (1994)

The Role of MbEGS1 and MbEGS2 in Methyleugenol Biosynthesis by Melaleuca bracteata
por: Lin, Yongsheng, et al.
Publicado: (2023)

5-Benzoyl-4-(4-fluorophenyl)-3,4-dihydropyrimidin-2(1H)-one
por: Kant, Rajni, et al.
Publicado: (2013)

Synthesis, Characterization, and Anticancer Activities Evaluation of Compounds Derived from 3,4-Dihydropyrimidin-2(1H)-one
por: Liu, Ye, et al.
Publicado: (2019)

Eg5 steps it up!
por: Valentine, Megan T, et al.
Publicado: (2006)

EGS4 Benchmark program
por: Yasu, Y, et al.
Publicado: (1995)

EG Wörterverzeichnis: Französisch - Deutsch
por: European Communities. Luxembourg. Council
Publicado: (1982)

The EGS4 code system
por: Nelson, Walter R, et al.
Publicado: (1985)

Copper(II) Sulfamate: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones and thiones
por: Liu, Chen-Jiang, et al.
Publicado: (2009)

Dataset on Insilico approaches for 3,4-dihydropyrimidin-2(1H)-one urea derivatives as efficient Staphylococcus aureus inhibitor
por: Oyebamiji, Abel Kolawole, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_21qb4dthl9l5guro3fi2kbhvl4