Cargando…
A light-inducible CRISPR/Cas9 system for control of endogenous gene activation
Optogenetic systems enable precise spatial and temporal control of cell behavior. We engineered a light-activated CRISPR/Cas9 effector (LACE) system that induces transcription of endogenous genes in the presence of blue light. This was accomplished by fusing the light-inducible heterodimerizing prot...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412021/ https://www.ncbi.nlm.nih.gov/pubmed/25664691 http://dx.doi.org/10.1038/nchembio.1753 |