Chronic enrichment of hepatic ER-mitochondria contact sites leads to calcium dependent mitochondrial dysfunction in obesity

Proper function of the endoplasmic reticulum (ER) and mitochondria is critical for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states including metabolic diseases. Although ER and mitochondria play distinct cellular roles, these organelles also form phy...

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Detalles Bibliográficos
Autores principales: Arruda, Ana Paula, Pers, Benedicte Mengel, Parlakgül, Güneş, Güney, Ekin, Inouye, Karen, Hotamisligil, Gökhan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412031/
https://www.ncbi.nlm.nih.gov/pubmed/25419710
http://dx.doi.org/10.1038/nm.3735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412031/
https://www.ncbi.nlm.nih.gov/pubmed/25419710
http://dx.doi.org/10.1038/nm.3735

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