Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A

BACKGROUND: Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study wa...

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Detalles Bibliográficos
Autores principales: Karrman, Kristina, Castor, Anders, Behrendtz, Mikael, Forestier, Erik, Olsson, Linda, Ehinger, Mats, Biloglav, Andrea, Fioretos, Thoas, Paulsson, Kajsa, Johansson, Bertil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412034/
https://www.ncbi.nlm.nih.gov/pubmed/25903014
http://dx.doi.org/10.1186/s13045-015-0138-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412034/
https://www.ncbi.nlm.nih.gov/pubmed/25903014
http://dx.doi.org/10.1186/s13045-015-0138-0

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