High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

We established co-cultures of invasive or non-invasive NSCLC cell lines and various types of fibroblasts (FBs) to more precisely characterize the molecular mechanism of tumor-stroma crosstalk in lung cancer. The HGF-MET-ERK1/2-CREB-axis was shown to contribute to the onset of the invasive phenotype...

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Detalles Bibliográficos
Autores principales: Rudisch, Albin, Dewhurst, Matthew Richard, Horga, Luminita Gabriela, Kramer, Nina, Harrer, Nathalie, Dong, Meng, van der Kuip, Heiko, Wernitznig, Andreas, Bernthaler, Andreas, Dolznig, Helmut, Sommergruber, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412534/
https://www.ncbi.nlm.nih.gov/pubmed/25919140
http://dx.doi.org/10.1371/journal.pone.0124283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412534/
https://www.ncbi.nlm.nih.gov/pubmed/25919140
http://dx.doi.org/10.1371/journal.pone.0124283

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