Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity

Monocarboxylate transporter 4 (MCT4) is a pH-dependent bi-directional lactate transporter. Transport of lactate via MCT4 is increased by extracellular acidification. We investigated the critical histidine residue involved in pH regulation of MCT4 function. Transport of lactate via MCT4 was measured...

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Detalles Bibliográficos
Autores principales: Sasaki, Shotaro, Kobayashi, Masaki, Futagi, Yuya, Ogura, Jiro, Yamaguchi, Hiroaki, Iseki, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412719/
https://www.ncbi.nlm.nih.gov/pubmed/25919709
http://dx.doi.org/10.1371/journal.pone.0122738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412719/
https://www.ncbi.nlm.nih.gov/pubmed/25919709
http://dx.doi.org/10.1371/journal.pone.0122738

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