A single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle

Toxoplasma gondii is the causative pathogen for Toxoplasmosis. Bumped kinase inhibitor 1NM-PP1 inhibits the growth of T. gondii by targeting TgCDPK1. However, we recently reported that resistance to 1NM-PP1 can be acquired via a mutation in T. gondii mitogen-activated protein kinase like 1 (TgMAPKL-...

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Detalles Bibliográficos
Autores principales: Sugi, Tatsuki, Kawazu, Shin-ichiro, Horimoto, Taisuke, Kato, Kentaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412912/
https://www.ncbi.nlm.nih.gov/pubmed/25941623
http://dx.doi.org/10.1016/j.ijpddr.2014.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412912/
https://www.ncbi.nlm.nih.gov/pubmed/25941623
http://dx.doi.org/10.1016/j.ijpddr.2014.12.001

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