‘Dopamine-first’ mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile

Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet–Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety. This unique activity has led to NCS being used for both in vitro biocatalysis and in vivo recombin...

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Detalles Bibliográficos
Autores principales: Lichman, Benjamin R, Gershater, Markus C, Lamming, Eleanor D, Pesnot, Thomas, Sula, Altin, Keep, Nicholas H, Hailes, Helen C, Ward, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413047/
https://www.ncbi.nlm.nih.gov/pubmed/25620686
http://dx.doi.org/10.1111/febs.13208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413047/
https://www.ncbi.nlm.nih.gov/pubmed/25620686
http://dx.doi.org/10.1111/febs.13208

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