Cargando…

‘Dopamine-first’ mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile

Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet–Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety. This unique activity has led to NCS being used for both in vitro biocatalysis and in vivo recombin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lichman, Benjamin R, Gershater, Markus C, Lamming, Eleanor D, Pesnot, Thomas, Sula, Altin, Keep, Nicholas H, Hailes, Helen C, Ward, John M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413047/ https://www.ncbi.nlm.nih.gov/pubmed/25620686 http://dx.doi.org/10.1111/febs.13208

Ejemplares similares

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase
por: Lichman, Benjamin R., et al.
Publicado: (2017)

Single step syntheses of (1S)-aryl-tetrahydroisoquinolines by norcoclaurine synthases
por: Roddan, Rebecca, et al.
Publicado: (2020)

Rational Engineering of (S)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis
por: De Sousa, João P. M., et al.
Publicado: (2023)

Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae
por: Li, Jing, et al.
Publicado: (2016)

Norcoclaurine Synthase: Mechanism of an Enantioselective Pictet-Spengler Catalyzing Enzyme
por: Bonamore, Alessandra, et al.
Publicado: (2010)

One–Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors
por: Pesnot, Thomas, et al.
Publicado: (2017)

Evolutionary origin of the NCSI gene subfamily encoding norcoclaurine synthase is associated with the biosynthesis of benzylisoquinoline alkaloids in plants
por: Vimolmangkang, Sornkanok, et al.
Publicado: (2016)

Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase
por: Guzman, Juan D., et al.
Publicado: (2015)

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues
por: Zhao, Jianxiong, et al.
Publicado: (2018)

Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines
por: Lichman, Benjamin R., et al.
Publicado: (2017)

Transcriptome Analysis of Stephania tetrandra and Characterization of Norcoclaurine-6-O-Methyltransferase Involved in Benzylisoquinoline Alkaloid Biosynthesis
por: Li, Kunlun, et al.
Publicado: (2022)

Crystal structures of the human Dysferlin inner DysF domain
por: Sula, Altin, et al.
Publicado: (2014)

Anti-Alzheimer and Antioxidant Effects of Nelumbo nucifera L. Alkaloids, Nuciferine and Norcoclaurine in Alloxan-Induced Diabetic Albino Rats
por: Khan, Shahnaz, et al.
Publicado: (2022)

Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil
por: Zha, Wenlong, et al.
Publicado: (2022)

Phylogeny-Aware Chemoinformatic Analysis of Chemical Diversity in Lamiaceae Enables Iridoid Pathway Assembly and Discovery of Aucubin Synthase
por: Rodríguez-López, Carlos E., et al.
Publicado: (2022)

Rational inattention and tonic dopamine
por: Mikhael, John G., et al.
Publicado: (2021)

Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
por: Erdmann, Vanessa, et al.
Publicado: (2017)

Training-induced plasticity enables visualizing sounds with a visual-to-auditory conversion device
por: Pesnot Lerousseau, Jacques, et al.
Publicado: (2021)

Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels
por: Sula, Altin, et al.
Publicado: (2017)

Nature's Chemists: The Discovery and Engineering of Phytochemical Biosynthesis
por: Eljounaidi, Kaouthar, et al.
Publicado: (2020)

Rational Engineering of Phenylalanine Accumulation in Pseudomonas taiwanensis to Enable High-Yield Production of Trans-Cinnamate
por: Otto, Maike, et al.
Publicado: (2019)

Structure-oriented substrate specificity engineering of aldehyde-deformylating oxygenase towards aldehydes carbon chain length
por: Bao, Luyao, et al.
Publicado: (2016)

An Aromatic Aldehyde Synthase Controls the Synthesis of Hydroxytyrosol Derivatives Present in Virgin Olive Oil
por: Sánchez, Rosario, et al.
Publicado: (2019)

Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags
por: Smith, Elizabeth L., et al.
Publicado: (2014)

Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
por: Kim, Hyun-Song, et al.
Publicado: (2022)

Practical Synthesis of C-1 Deuterated Aldehydes Enabled by NHC Catalysis
por: Geng, Huihui, et al.
Publicado: (2019)

Rational engineering enables co-crystallization and structural determination of the HIV-1 matrix-tRNA complex
por: Bou-Nader, Charles, et al.
Publicado: (2021)

Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage‐gated sodium channel NavMs
por: Ireland, Sam M., et al.
Publicado: (2017)

Computer Simulation to Rationalize “Rational” Engineering of Glycoside Hydrolases and Glycosyltransferases
por: Coines, Joan, et al.
Publicado: (2022)

Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry
por: Sherden, Nathaniel H., et al.
Publicado: (2018)

Prebiotically Plausible Organocatalysts Enabling a Selective Photoredox α‐Alkylation of Aldehydes on the Early Earth
por: Closs, Anna C., et al.
Publicado: (2020)

Engineering Polyketide Synthases
por: Katz, Leonard
Publicado: (2002)

Electrochemically Generated Carbanions Enable Isomerizing Allylation and Allenylation of Aldehydes with Alkenes and Alkynes
por: Zhang, Sheng, et al.
Publicado: (2023)

Engineering Clostridial Aldehyde/Alcohol Dehydrogenase for Selective Butanol Production
por: Cho, Changhee, et al.
Publicado: (2019)

Rational and semi-rational engineering of cytochrome P450s for biotechnological applications
por: Xu, Lian-Hua, et al.
Publicado: (2018)

Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
por: Drufva, Erin E., et al.
Publicado: (2020)

Rationalization of allosteric pathway in Thermus sp. GH5 methylglyoxal synthase
por: Zareian, Shekufeh, et al.
Publicado: (2012)

Laccase engineering by rational and evolutionary design
por: Pardo, Isabel, et al.
Publicado: (2015)

Rationally engineered advances in cancer research
por: Engler, Adam J., et al.
Publicado: (2018)

The blind watchmaker and rational protein engineering
por: Anthonsen, Henrik W., et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_6t6pq6dqsloq6datfs14k781hm