Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs

Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC(50) = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoji, Lv, Chanshan, Feng, Junmin, Tang, Linjun, Wang, Zhuo, Liu, Yuqing, Meng, Yi, Ye, Tao, Xu, Zhengshuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413201/
https://www.ncbi.nlm.nih.gov/pubmed/25871289
http://dx.doi.org/10.3390/md13042085
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author Wang, Xiaoji
Lv, Chanshan
Feng, Junmin
Tang, Linjun
Wang, Zhuo
Liu, Yuqing
Meng, Yi
Ye, Tao
Xu, Zhengshuang
author_facet Wang, Xiaoji
Lv, Chanshan
Feng, Junmin
Tang, Linjun
Wang, Zhuo
Liu, Yuqing
Meng, Yi
Ye, Tao
Xu, Zhengshuang
author_sort Wang, Xiaoji
collection PubMed
description Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC(50) = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners.
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spelling pubmed-44132012015-05-07 Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs Wang, Xiaoji Lv, Chanshan Feng, Junmin Tang, Linjun Wang, Zhuo Liu, Yuqing Meng, Yi Ye, Tao Xu, Zhengshuang Mar Drugs Article Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC(50) = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners. MDPI 2015-04-13 /pmc/articles/PMC4413201/ /pubmed/25871289 http://dx.doi.org/10.3390/md13042085 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Xiaoji
Lv, Chanshan
Feng, Junmin
Tang, Linjun
Wang, Zhuo
Liu, Yuqing
Meng, Yi
Ye, Tao
Xu, Zhengshuang
Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
title Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
title_full Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
title_fullStr Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
title_full_unstemmed Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
title_short Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
title_sort studies toward the total synthesis of itralamide b and biological evaluation of its structural analogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413201/
https://www.ncbi.nlm.nih.gov/pubmed/25871289
http://dx.doi.org/10.3390/md13042085
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