Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling

Avarol is a sesquiterpenoid hydroquinone with potent cytotoxicity. Although resolving endoplasmic reticulum (ER) stress is essential for intracellular homeostasis, erratic or excessive ER stress can lead to apoptosis. Here, we reported that avarol selectively induces cell death in pancreatic ductal...

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Detalles Bibliográficos
Autores principales: Namba, Takushi, Kodama, Rika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413216/
https://www.ncbi.nlm.nih.gov/pubmed/25894488
http://dx.doi.org/10.3390/md13042376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413216/
https://www.ncbi.nlm.nih.gov/pubmed/25894488
http://dx.doi.org/10.3390/md13042376

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