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New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures ar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413224/ https://www.ncbi.nlm.nih.gov/pubmed/25913707 http://dx.doi.org/10.3390/md13042526 |
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author | Niu, Siwen Liu, Dong Proksch, Peter Shao, Zongze Lin, Wenhan |
author_facet | Niu, Siwen Liu, Dong Proksch, Peter Shao, Zongze Lin, Wenhan |
author_sort | Niu, Siwen |
collection | PubMed |
description | Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents. |
format | Online Article Text |
id | pubmed-4413224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44132242015-05-07 New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities Niu, Siwen Liu, Dong Proksch, Peter Shao, Zongze Lin, Wenhan Mar Drugs Article Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents. MDPI 2015-04-22 /pmc/articles/PMC4413224/ /pubmed/25913707 http://dx.doi.org/10.3390/md13042526 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Niu, Siwen Liu, Dong Proksch, Peter Shao, Zongze Lin, Wenhan New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
title | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
title_full | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
title_fullStr | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
title_full_unstemmed | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
title_short | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
title_sort | new polyphenols from a deep sea spiromastix sp. fungus, and their antibacterial activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413224/ https://www.ncbi.nlm.nih.gov/pubmed/25913707 http://dx.doi.org/10.3390/md13042526 |
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