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New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities

Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures ar...

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Autores principales: Niu, Siwen, Liu, Dong, Proksch, Peter, Shao, Zongze, Lin, Wenhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413224/
https://www.ncbi.nlm.nih.gov/pubmed/25913707
http://dx.doi.org/10.3390/md13042526
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author Niu, Siwen
Liu, Dong
Proksch, Peter
Shao, Zongze
Lin, Wenhan
author_facet Niu, Siwen
Liu, Dong
Proksch, Peter
Shao, Zongze
Lin, Wenhan
author_sort Niu, Siwen
collection PubMed
description Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents.
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spelling pubmed-44132242015-05-07 New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities Niu, Siwen Liu, Dong Proksch, Peter Shao, Zongze Lin, Wenhan Mar Drugs Article Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents. MDPI 2015-04-22 /pmc/articles/PMC4413224/ /pubmed/25913707 http://dx.doi.org/10.3390/md13042526 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Niu, Siwen
Liu, Dong
Proksch, Peter
Shao, Zongze
Lin, Wenhan
New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
title New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
title_full New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
title_fullStr New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
title_full_unstemmed New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
title_short New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
title_sort new polyphenols from a deep sea spiromastix sp. fungus, and their antibacterial activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413224/
https://www.ncbi.nlm.nih.gov/pubmed/25913707
http://dx.doi.org/10.3390/md13042526
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