Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

Statins, such as lovastatin, can induce a cell cycle arrest in the G1 phase. This robust antiproliferative activity remains intact in many cancer cells that are deficient in cell cycle checkpoints and leads to an increased expression of CDK inhibitor proteins p27(Kip1) and p21(Cip1). The molecular d...

Descripción completa

Detalles Bibliográficos
Autores principales: Vosper, Jonathan, Masuccio, Alessia, Kullmann, Michael, Ploner, Christian, Geley, Stephan, Hengst, Ludger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413625/
https://www.ncbi.nlm.nih.gov/pubmed/25605247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413625/
https://www.ncbi.nlm.nih.gov/pubmed/25605247

Ejemplares similares