Cargando…

Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

Statins, such as lovastatin, can induce a cell cycle arrest in the G1 phase. This robust antiproliferative activity remains intact in many cancer cells that are deficient in cell cycle checkpoints and leads to an increased expression of CDK inhibitor proteins p27(Kip1) and p21(Cip1). The molecular d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vosper, Jonathan, Masuccio, Alessia, Kullmann, Michael, Ploner, Christian, Geley, Stephan, Hengst, Ludger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413625/ https://www.ncbi.nlm.nih.gov/pubmed/25605247

Ejemplares similares

Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity
por: Wang, Lai, et al.
Publicado: (2022)

Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes Ferroptosis-Related Senescence in Adipose Tissue
por: Shu, Xin, et al.
Publicado: (2022)

Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes PCSK9–Dependent Adipose Insulin Resistance
por: Shu, Xin, et al.
Publicado: (2022)

Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate
por: Li, Min, et al.
Publicado: (2020)

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma
por: Yanae, Masashi, et al.
Publicado: (2011)

The p27–Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells
por: Kullmann, Michael K, et al.
Publicado: (2013)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Stimulation of c-Jun/AP-1-Activity by the Cell Cycle Inhibitor p57(Kip2)
por: Kullmann, Michael Keith, et al.
Publicado: (2021)

Functional Characterization of the Xanthophyllomyces dendrorhous Farnesyl Pyrophosphate Synthase and Geranylgeranyl Pyrophosphate Synthase Encoding Genes That Are Involved in the Synthesis of Isoprenoid Precursors
por: Alcaíno, Jennifer, et al.
Publicado: (2014)

p27(Kip1) – p(RhoB)lematic in lung cancer
por: Podmirseg, Silvio R, et al.
Publicado: (2019)

Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii Briq
por: Engprasert, Surang, et al.
Publicado: (2004)

Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis
por: Feng, Yuchi, et al.
Publicado: (2020)

Relationship between β-Carotene Accumulation and Geranylgeranyl Pyrophosphate Synthase in Different Species of Dunaliella
por: Xu, Lu, et al.
Publicado: (2021)

BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis
por: Grespi, Francesca, et al.
Publicado: (2010)

Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells
por: Tanaka, Shou, et al.
Publicado: (2019)

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
por: Bibby, Jack A., et al.
Publicado: (2020)

Genome-wide identification of the geranylgeranyl pyrophosphate synthase (GGPS) gene family involved in chlorophyll synthesis in cotton
por: Feng, Wenxiang, et al.
Publicado: (2023)

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
por: Baron, Rudi A., et al.
Publicado: (2009)

Heterologous expression of chloroplast‐localized geranylgeranyl pyrophosphate synthase confers fast plant growth, early flowering and increased seed yield
por: Tata, Sandeep Kumar, et al.
Publicado: (2015)

Corynebacterium glutamicum CrtR and Its Orthologs in Actinobacteria: Conserved Function and Application as Genetically Encoded Biosensor for Detection of Geranylgeranyl Pyrophosphate
por: Henke, Nadja A., et al.
Publicado: (2020)

Discovery of Geranylgeranyl Pyrophosphate Synthase (GGPPS) Paralogs from Haematococcus pluvialis Based on Iso-Seq Analysis and Their Function on Astaxanthin Biosynthesis
por: Huang, Danqiong, et al.
Publicado: (2019)

A Sweetpotato Geranylgeranyl Pyrophosphate Synthase Gene, IbGGPS, Increases Carotenoid Content and Enhances Osmotic Stress Tolerance in Arabidopsis thaliana
por: Chen, Wei, et al.
Publicado: (2015)

Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27(Kip1)
por: Roilo, Martina, et al.
Publicado: (2018)

Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation
por: Agabiti, Sherry S, et al.
Publicado: (2017)

Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis
por: Kato, Shota, et al.
Publicado: (2016)

Pitavastatin Induces Apoptosis of Cutaneous Squamous Cell Carcinoma Cells through Geranylgeranyl Pyrophosphate-Dependent c-Jun N-Terminal Kinase Activation
por: Kim, Kyung-Il, et al.
Publicado: (2023)

PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation
por: Dou, Xiaoyan, et al.
Publicado: (2015)

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation
por: Fu, Hang, et al.
Publicado: (2019)

Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts
por: Connor, Alison M, et al.
Publicado: (2006)

Inhibiting RHO geranylgeranylation has an unexpected outcome on inflammation
Publicado: (2011)

The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation
por: Dui, Wen, et al.
Publicado: (2013)

The CDK inhibitor p57(Kip2) enhances the activity of the transcriptional coactivator FHL2
por: Kullmann, Michael Keith, et al.
Publicado: (2020)

Identification and Functional Analysis of Two Novel Genes—Geranylgeranyl Pyrophosphate Synthase Gene (AlGGPPS) and Isopentenyl Pyrophosphate Isomerase Gene (AlIDI)—from Aurantiochytrium limacinum Significantly Enhance De Novo β-Carotene Biosynthesis in Escherichia coli
por: Shi, Shitao, et al.
Publicado: (2023)

A quantitative method to measure geranylgeranyl diphosphate (GGPP) and geranylgeranyl monophosphate (GGP) in tomato (Solanum lycopersicum) fruit
por: Zita, Wayne, et al.
Publicado: (2023)

Skp2 modulates proliferation, senescence and tumorigenesis of glioma
por: Wu, Juan, et al.
Publicado: (2020)

Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma
por: Wang, Jichuan, et al.
Publicado: (2020)

Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells
por: Ishihara, Noriko, et al.
Publicado: (2017)

Towards Complete Sets of Farnesylated and Geranylgeranylated Proteins
por: Maurer-Stroh, Sebastian, et al.
Publicado: (2007)

Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion
por: Grote, Eric, et al.
Publicado: (2000)

Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
por: Agabiti, Sherry S., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_i9r7d0uialj8mvmi3j6evl8b6i