Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

Tyrosine kinase inhibitors, affecting angiogenesis, have shown therapeutic efficacy in renal cell carcinoma (RCC). The increased overall survival is not fully explained by their anti-tumor activity, since these drugs frequently induce disease stabilization rather than regression. RCC patients freque...

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Detalles Bibliográficos
Autores principales: Pretto, Francesca, Ghilardi, Carmen, Moschetta, Michele, Bassi, Andrea, Rovida, Alessandra, Scarlato, Valentina, Talamini, Laura, Fiordaliso, Fabio, Bisighini, Cinzia, Damia, Giovanna, Bani, Maria Rosa, Piccirillo, Rosanna, Giavazzi, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413636/
https://www.ncbi.nlm.nih.gov/pubmed/25460504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413636/
https://www.ncbi.nlm.nih.gov/pubmed/25460504

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