Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

Despite the clinical benefit of the proteasome inhibitor bortezomib, multiple myeloma (MM) patients invariably relapse through poorly defined mechanisms. Myeloma cells inevitably develop chemoresistance that leads to disease relapse and patient-related deaths. Studies in tumor cell lines and biopsie...

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Detalles Bibliográficos
Autores principales: Abdel Malek, Mohamed A.Y., Jagannathan, Sajjeev, Malek, Ehsan, Sayed, Douaa M., Elgammal, Sahar A., Abd El-Azeem, Hanan G., Thabet, Nabila M., Driscoll, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413640/
https://www.ncbi.nlm.nih.gov/pubmed/25605012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413640/
https://www.ncbi.nlm.nih.gov/pubmed/25605012

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