MYC is a critical target of FBXW7

MYC deregulation is a driver of many human cancers. Altering the balance of MYC protein levels at the level of transcription, protein stability, or turnover is sufficient to transform cells to a tumorigenic phenotype. While direct targeting of MYC is difficult, specific genetic vulnerabilities of MY...

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Detalles Bibliográficos
Autores principales: Sato, Mai, Rodriguez-Barrueco, Ruth, Yu, Jiyang, Do, Catherine, Silva, Jose M., Gautier, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413654/
https://www.ncbi.nlm.nih.gov/pubmed/25669969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413654/
https://www.ncbi.nlm.nih.gov/pubmed/25669969

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