Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes. While bacteria and phage simply recruit polymerases to the fork, we find that suppression mechanisms are used to position th...

Descripción completa

Detalles Bibliográficos
Autores principales: Georgescu, Roxana E, Schauer, Grant D, Yao, Nina Y, Langston, Lance D, Yurieva, Olga, Zhang, Dan, Finkelstein, Jeff, O'Donnell, Mike E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413876/
https://www.ncbi.nlm.nih.gov/pubmed/25871847
http://dx.doi.org/10.7554/eLife.04988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413876/
https://www.ncbi.nlm.nih.gov/pubmed/25871847
http://dx.doi.org/10.7554/eLife.04988

Ejemplares similares