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Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture
BACKGROUND: Adoptive transfer of minor histocompatibility antigen (MiHA)-specific T cells is a promising therapy for patients with hematological cancers. However, the efficacy of the transferred cells is hampered by the acquisition of terminal effector differentiation and exhaustion features during...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413989/ https://www.ncbi.nlm.nih.gov/pubmed/25925868 http://dx.doi.org/10.1186/s12967-015-0495-z |