Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

The aim of this study was to determine whether autophagy and AMPK contribute to premature senescence in auditory cells. Incubating HEI-OC1 auditory cells with 5 mM H(2)O(2) for 1 h induced senescence, as demonstrated by senescence-associated β-galactosidase (SA-β-gal) staining. H(2)O(2) treatment si...

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Detalles Bibliográficos
Autores principales: Tsuchihashi, Nana Akagi, Hayashi, Ken, Dan, Katsuaki, Goto, Fumiyuki, Nomura, Yasuyuki, Fujioka, Masato, Kanzaki, Sho, Komune, Shizuo, Ogawa, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Gerotarget (Focus on Aging): Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414143/
https://www.ncbi.nlm.nih.gov/pubmed/25682865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414143/
https://www.ncbi.nlm.nih.gov/pubmed/25682865

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