MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma

MicroRNA-10b (miR-10b) is commonly elevated in glioblastoma (GBM), while not expressed in normal brain tissues. Targeted inhibition of miR-10b has pleiotropic effects on GBM derived cell lines, it reduces GBM growth in animal models, but does not affect normal neurons and astrocytes. This data raise...

Descripción completa

Detalles Bibliográficos
Autores principales: Teplyuk, Nadiya M., Uhlmann, Erik J., Wong, Andus Hon-Kit, Karmali, Priya, Basu, Meenakshi, Gabriely, Galina, Jain, Anant, Wang, Yang, Chiocca, E. Antonio, Stephens, Robert, Marcusson, Eric, Yi, Ming, Krichevsky, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414152/
https://www.ncbi.nlm.nih.gov/pubmed/25738367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414152/
https://www.ncbi.nlm.nih.gov/pubmed/25738367

Ejemplares similares