MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma

MicroRNA-10b (miR-10b) is commonly elevated in glioblastoma (GBM), while not expressed in normal brain tissues. Targeted inhibition of miR-10b has pleiotropic effects on GBM derived cell lines, it reduces GBM growth in animal models, but does not affect normal neurons and astrocytes. This data raise...

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Detalles Bibliográficos
Autores principales: Teplyuk, Nadiya M., Uhlmann, Erik J., Wong, Andus Hon-Kit, Karmali, Priya, Basu, Meenakshi, Gabriely, Galina, Jain, Anant, Wang, Yang, Chiocca, E. Antonio, Stephens, Robert, Marcusson, Eric, Yi, Ming, Krichevsky, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414152/
https://www.ncbi.nlm.nih.gov/pubmed/25738367

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